Format

Send to

Choose Destination
Cell Stress Chaperones. 2000 Jul;5(3):219-28.

Formation of nuclear HSF1 granules varies depending on stress stimuli.

Author information

1
Turku Centre for Biotechnology, University of Turku, Abo Akademi University, Finland.

Abstract

In concert with the stress-induced activation of human heat shock factor 1 (HSF1), the factor becomes inducibly phosphorylated and accumulates into nuclear granules. To date, these processes are not fully understood. Here, we show that although stress caused by the proteasome inhibitors MG132 and clasto-lactacystine beta-lactone induces the expression of Hsp70, the formation of HSF1 granules is affected differently in comparison to heat shock. Furthermore, proteasome inhibition increases serine phosphorylation on HSF1, but to a lesser extent than heat stress. Our results suggest that, depending on the type of stress stimulus, the multiple events associated with HSF1 activation might be affected differently.

PMID:
11005380
PMCID:
PMC312888
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center