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Transplantation. 2000 Sep 15;70(5):800-1.

Therapy of visceral leishmaniasis in renal transplant recipients intolerant to pentavalent antimonials.

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Nephrology Service, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.


Visceral leishmaniasis should be suspected in renal transplant recipients in whom a fever develops of unknown origin. A 53-year-old renal transplant recipient developed pyrexia, hepatosplenomegaly, and pancytopenia 4 years after transplantation. Antileishmaniasis serology was negative, and the diagnosis was confirmed through bone marrow examination. Treatment with glucantine (N-methylglucamine antimoniate) led to acute pancreatitis, and treatment with ketoconazole plus allopurinol for 21 days was effective to eradicate Leishmania donovani.

[Indexed for MEDLINE]

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