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Bioorg Med Chem Lett. 2000 Sep 18;10(18):2119-22.

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists.

Author information

1
Neurogen Corporation, Branford, CT 06405, USA. hzhao@nrgn.com

Abstract

3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (delta-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (gamma-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (epsilon-lactams) were also prepared and examined.

PMID:
10999484
DOI:
10.1016/s0960-894x(00)00421-2
[Indexed for MEDLINE]

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