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Trends Cell Biol. 2000 Oct;10(10):415-9.

Rho family GTPases: more than simple switches.

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Picower Institute for Molecular Research, 350 Community Drive, Manhasset, NY 11030, USA.


Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.

[Indexed for MEDLINE]

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