Format

Send to

Choose Destination
See comment in PubMed Commons below
Peptides. 2000 Jul;21(7):1051-62.

The hyperphagic effect of nociceptin/orphanin FQ in rats.

Author information

1
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032, Camerino, Italy. polidori@cambio.unicam.it

Abstract

Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperphagic effect of NC in rats. The results obtained indicate that the hypothalamic arcuate nucleus is the most sensitive site among the brain regions so far investigated. On the basis of these findings and of the neurochemical and electrophysiological effects of NC, possible mechanisms of action and possible interactions with other neurotransmitter systems affecting feeding are discussed.

PMID:
10998540
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center