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Emerg Infect Dis. 2000 Sep-Oct;6(5):505-12.

Comparative genomics and understanding of microbial biology.

Author information

1
The Institute for Genomic Research, Rockville, Maryland 20850, USA. cmfraser@tigr.org

Abstract

The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.

PMID:
10998382
PMCID:
PMC2627966
DOI:
10.3201/eid0605.000510
[Indexed for MEDLINE]
Free PMC Article

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