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Neurosci Res. 2000 Sep;38(1):113-6.

Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia.

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1
Laboratory for Neurobiology of Emotion, RIKEN, Brain Science Institute, Wako, Saitama, Japan. ikedak@postman.riken.go.jp

Abstract

To investigate the role of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia, we compared the effects of opioids in wild-type and weaver mutant mice having mutant GIRK channels. In the tail-flick and hot-plate tests, weaver mutant mice displayed significantly lower analgesia after either morphine or (-)-U-50488 administration. These findings suggest that GIRK channel activation is important in the induction of analgesia by opioids.

PMID:
10997585
[Indexed for MEDLINE]
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