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Curr Biol. 2000 Sep 21;10(18):R678-81.

Translocases: a bacterial tunnel for drugs and proteins.

Author information

1
Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA. klewis@tufts.edu

Abstract

Unrelated translocases extrude proteins or antimicrobial agents across both membranes of the cell envelope in Gram-negative bacteria. The TolC protein links the translocases to the external environment. The recently determined crystal structure of TolC shows how this universal tunnel operates.

PMID:
10996810
DOI:
10.1016/s0960-9822(00)00682-5
[Indexed for MEDLINE]
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