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Clin Neurophysiol. 2000 Sep;111 Suppl 2:S9-S18.

Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation.

Author information

1
Sleep Disturbance Research (151A3), Sepulveda Campus, VA Greater Los Angeles Health Care System (VAGLAHS), Sepulveda, CA 91343, USA. nshouse@ucla.edu

Abstract

OBJECTIVES:

To describe how the neural generators of different sleep components can provoke seizure discharge propagation during NREM sleep and can suppress it during REM sleep.

METHODS:

Experimental manipulations of discrete physiological components were conducted in feline epilepsy models (n=64), mostly in the systemic penicillin epilepsy model of primary generalized epilepsy and the amygdala kindling model of the localization-related seizure disorder, temporal lobe epilepsy. Procedures included seizure induction as well as quantifying norepinephrine concentrations (microdialysis) and the sleep-waking state distribution of seizures before and after lesions, systemic and localized drug administration and/or photic stimulation.

RESULTS:

(1) Neural generators of synchronous EEG oscillations, including tonic background slow waves and phasic 'arousal' events (sleep EEG transients such as sleep spindles, k-complexes), can combine to promote electrographic seizure propagation during NREM and drowsiness; anti-gravity muscle tone permits seizure-related movement. (2) Neural generators of asynchronous neuronal discharge patterns can reduce electrographic seizures during alert waking and REM sleep; skeletal motor paralysis blocks seizure-related movement during REM. (3) Etiology of the seizure disorder can interact with sleep and arousal mechanisms to determine sleep-waking state distribution of interictal and ictal events.

CONCLUSIONS:

Differential effects of NREM versus REM sleep components on seizure discharge propagation are to some extent non-specific and in other ways specific to seizure etiology.

PMID:
10996550
DOI:
10.1016/s1388-2457(00)00397-7
[Indexed for MEDLINE]

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