Format

Send to

Choose Destination
See comment in PubMed Commons below
J Reprod Immunol. 2000 Aug;48(1):17-26.

HLA-G suppresses proliferation of CD4(+) T-lymphocytes.

Author information

1
Reproduction and Development Group, Royal Veterinary College, Boltons Park, Hawkshead Road, EN6 1NB, Potters Bar, UK. dbainbridge@rvc.ac.uk

Abstract

HLA-G is a non-classical MHC class 1 molecule, expressed primarily on human foetal trophoblast cells, which exhibits almost no genetic polymorphism. Because of these unusual features, HLA-G has been suggested to help prevent maternal immune attack of the semi-allogeneic foetus. The aim of these experiments was to investigate the effects of HLA-G on T-lymphocyte responses by using MHC class II-bearing HLA-G transfectants as stimulators of a mixed lymphocyte reaction. The presence of HLA-G, but not classical HLA class I, on the surface of stimulator cells markedly suppressed thymidine incorporation by peripheral blood mononuclear responder cells from a class I-similar, class II-dissimilar male. The suppressive effect of HLA-G on the mixed lymphocyte reaction persisted after depletion of phagocytes and CD8(+) T-cells from the responder population, but the mixed lymphocyte reaction was entirely abolished by depletion of CD4(+) T-cells. These results suggest that HLA-G exerts a direct suppressive effect on CD4(+) T-lymphocytes, even in the absence of the CD8(+) cells with which other human MHC class I molecules are thought to interact. Thus, HLA-G may allow the foetus to escape maternal immune attack by modulating CD4(+) T-cell activity.

PMID:
10996380
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center