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Brain Res. 2000 Sep 29;878(1-2):218-22.

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.

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Department of Neurology, Kentucky Clinic, Room L-445, University of Kentucky, Lexington, KY 40536-0284, USA.


We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration.

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