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Phys Rev Lett. 2000 Jun 5;84(23):5447-50.

Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks.

Author information

1
Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, Uppsala, 75124 Sweden. Johann.Paulsson@icm.uu.se

Abstract

Many intracellular components are present in low copy numbers per cell and subject to feedback control. We use chemical master equations to analyze a negative feedback system where species X and S regulate each other's synthesis with standard intracellular kinetics. For a given number of X-molecules, S-variation can be significant. We show that this signal noise does not necessarily increase X-variation as previously thought but, surprisingly, can be necessary to reduce it below a Poissonian limit. The principle resembles Stochastic Resonance in that signal noise improves signal detection.

PMID:
10990965
DOI:
10.1103/PhysRevLett.84.5447
[Indexed for MEDLINE]

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