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Phys Rev Lett. 2000 May 22;84(21):5014-7.

Femtonewton force spectroscopy of single extended DNA molecules.

Author information

1
Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA.

Abstract

We studied the thermal fluctuations of single DNA molecules with a novel optical tweezer based force spectroscopy technique. This technique combines femtonewton sensitivity with millisecond time resolution, surpassing the sensitivity of previous force measurements in aqueous solution with comparable bandwidth by a hundredfold. Our data resolve long-standing questions concerning internal hydrodynamics of the polymer and anisotropy in the molecular relaxation times and friction coefficients. The dynamics at high extension show interesting nonlinear behavior.

PMID:
10990855
DOI:
10.1103/PhysRevLett.84.5014
[Indexed for MEDLINE]

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