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Trends Microbiol. 2000 Sep;8(9):419-25.

CD1 and CD1-restricted T cells in infections with intracellular bacteria.

Author information

1
Max-Planck-Institute for Infection Biology, Schumannstrbetae 21/22, D-10117, Berlin, Germany. schiable@mpiib-berlin@mpg.de

Abstract

Glycolipid-specific, CD1a-, b- and c-dependent cytotoxic T cells have recently been shown to be involved in the host response against tuberculosis. These CD1 molecules 'sample' mycobacterial glycolipids from different intracellular sites in the infected cell. Additionally, upon microbial encounter, CD1d-dependent natural killer T cells promptly produce cytokines and perform regulatory activities. Here, we discuss the intracellular localization of CD1 molecules and mycobacterial lipids and the role of CD1-mediated T-cell responses in mycobacterial infections.

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PMID:
10989309
DOI:
10.1016/s0966-842x(00)01829-1
[Indexed for MEDLINE]

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