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Mech Ageing Dev. 2000 Sep 1;118(1-2):1-14.

Transgenic methods for increasing Drosophila life span.

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Department of Biological Sciences, SHS172, University of Southern California, Los Angeles, CA 90089-1340, USA.


At least five different transgenic approaches have been applied to the study of Drosophila aging. There are two single component systems: transgenes with native (normal) promoters and transgenes with heterologous promoters; as well as three binary systems: 'GAL4/UAS', 'FLP-out' and 'tet-on'. These approaches vary in ability to meet several technical challenges, and the relative advantages and disadvantages of each are discussed. Using these techniques, over-expression of the hsp70, Cu/ZnSOD and MnSOD genes has each been demonstrated to increase Drosophila life span.

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