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Glycobiology. 2000 Sep;10(9):849-56.

Carbohydrate sulfotransferases in lymphocyte homing.

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Department of Respiratory Diseases, Roche Bioscience, Palo Alto, CA 94304-1397, USA.


Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.

[Indexed for MEDLINE]

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