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Bioorg Med Chem Lett. 2000 Sep 4;10(17):2041-4.

Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.

Author information

1
Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Erlangen, Germany.

Abstract

Conformationally restricted benzamide bioisosteres were investigated when the aminomethylpyrrolidine derivative 4o proved D3 as well as D4 binding properties which were comparable to those of the atypical neuroleptics sulpiride and clozapine, respectively.

PMID:
10987445
DOI:
10.1016/s0960-894x(00)00405-4
[Indexed for MEDLINE]

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