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Exp Toxicol Pathol. 2000 Aug;52(4):312-6.

Synovial giant cells in rheumatoid arthritis: expression of cystatin C, but not of cathepsin B.

Author information

1
Johannes Gutenberg University Mainz, Institute for Pathology, Germany.

Abstract

This study was designed to investigate the expression of the matrix degrading proteinase cathepsin B and its endogenous inhibitor cystatin C in rheumatoid arthritis (RA) with special regard to multinucleated synovial giant cells (SGC). We applied an immunohistochemical double-labeling technique. SGC strongly expressed cystatin C and CD68, but were negative for cathepsin B. This staining pattern occurred in osteoclasts as well. Our findings support the idea that in RA matrix destruction by cathepsin B is not mediated by SGC or osteoclasts, but by mononuclear synoviocytes.

PMID:
10987183
DOI:
10.1016/S0940-2993(00)80055-X
[Indexed for MEDLINE]

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