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Neuron. 2000 Aug;27(2):371-83.

Receptive field microstructure and dendritic geometry of retinal ganglion cells.

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1
Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

We studied the fine spatial structure of the receptive fields of retinal ganglion cells and its relationship to the dendritic geometry of these cells. Cells from which recordings had been made were microinjected with Lucifer yellow, so that responses generated at precise locations within the receptive field center could be directly compared with that cell's dendritic structure. While many cells with small receptive fields had domeshaped sensitivity profiles, the majority of large receptive fields were composed of multiple regions of high sensitivity. The density of dendritic branches at any one location did not predict the regions of high sensitivity. Instead, the interactions between a ganglion cell's dendritic tree and the local mosaic of bipolar cell axons seem to define the fine structure of the receptive field center.

PMID:
10985356
[Indexed for MEDLINE]
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