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Genome Res. 2000 Sep;10(9):1288-303.

Automation for genomics, part two: sequencers, microarrays, and future trends.

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Department of Electrical Engineering, Genomation Laboratory, University of Washington, Seattle, Washington 98195-2500, USA.


Automation for genomics has enabled a 43-fold increase in the total finished human genomic sequence in the world in the past four years. This is the second half of a two-part, noncomprehensive review that presents an overview of different types of automation equipment used in genome sequencing. The first part of the review, published in the previous issue, focused on automated procedures used to prepare DNA for sequencing or analysis. This second part of the review presents a look at available DNA sequencers and array technology and concludes with a look at future technologies. Alternate sequencing technologies including mass spectrometry, biochips, and single molecule analysis are included in this review.

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