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Antisense Nucleic Acid Drug Dev. 2000 Aug;10(4):297-310.

Heterocyclic modifications of oligonucleotides and antisense technology.

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  • 1Rega Institute for Medical Research, K.U. Leuven, Laboratory for Medicinal Chemistry, Belgium.


Modification of the heterocyclic moiety of oligonucleotides has led to the discovery of potent antisense compounds. This review describes the physicochemical factors that are responsible for duplex stabilization through base modification. A summary is given of the different heterocyclic modifications that can be used to beneficially influence this duplex stability. The biologic activity of base-modified oligonucleotides is described, and the different factors that are important for obtaining in vivo antisense activity with heterocyclic-modified oligonucleotides are summarized.

[PubMed - indexed for MEDLINE]
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