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Curr Opin Struct Biol. 2000 Aug;10(4):448-55.

Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.

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Graduate Option in Biochemistry, California Institute of Technology, Pasadena 91125, USA.


The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.

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