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Curr Opin Struct Biol. 2000 Aug;10(4):411-6.

Advances in zinc finger engineering.

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Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.


Recently developments have been made in engineering sequence-specific zinc finger DNA-binding proteins. Advances in this area will soon make it routine to target proteins to specific DNA sequences associated with any given gene. The primary interest is in the regulation of gene expression using customised transcription factors. However, modular catalytic domains are also being developed in order to engineer chimaeric proteins with customised restriction enzyme, methylase and integrase activity.

[Indexed for MEDLINE]

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