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Neurology. 2000 Sep 12;55(5):708-10.

Early diagnosis of zoster sine herpete and antiviral therapy for the treatment of facial palsy.

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  • 1Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan.


The effect of antiviral agents on recovery from facial palsy in patients with zoster sine herpete (ZSH; varicella zoster virus reactivation without zoster) has not been evaluated because ZSH is difficult to diagnose early after onset. In this study, all 13 patients who received acyclovir-prednisone treatment within 7 days of onset, as confirmed by a positive PCR result, showed complete recovery. PCR-based early diagnosis of ZSH and antiviral therapy elicited an excellent outcome for recovery from facial palsy due to ZSH.

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