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Nat Cell Biol. 2000 Sep;2(9):666-8.

Mechanical control of cyclic AMP signalling and gene transcription through integrins.

Author information

1
Departments of Pathology and Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
2
Children's Hosp, Boston, MA

Abstract

This study was carried out to discriminate between two alternative hypotheses as to how cells sense mechanical forces and transduce them into changes in gene transcription. Do cells sense mechanical signals through generalized membrane distortion or through specific transmembrane receptors, such as integrins? Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect.

PMID:
10980709
DOI:
10.1038/35023621
[Indexed for MEDLINE]

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