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Curr Opin Cell Biol. 2000 Oct;12(5):606-12.

Remarkable roles of proteolysis on and beyond the cell surface.

Author information

1
Cellular Biochemistry and Biophysics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA. c-blobel@ski.mskcc.org

Abstract

Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.

PMID:
10978897
DOI:
10.1016/s0955-0674(00)00139-3
[Indexed for MEDLINE]

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