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Curr Opin Cell Biol. 2000 Oct;12(5):554-62.

Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion.

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Fred Hutchinson Cancer Research Center, Division of Basic Sciences, A3-015, 1100 Fairview Avenue North, Washington 98109, Seattle, USA.


Adhesion of keratinocytes in a wound outgrowth to laminin 5 in the basement membrane via integrins alpha6beta4 and alpha3beta1 is distinct from adhesion to dermal collagen via alpha2beta1 or to fibronectin via alpha5beta1. Leading cells in the outgrowth are distinguished from following keratinocytes by deposition of laminin 5, failure to communicate via gap junctions and sensitivity to toxin B, an inhibitor of RhoGTPase. Laminin 5 deposited by leading keratinocytes onto dermal collagen dominates over dermal ligands and changes the cell signals required for adhesion from collagen-dependent to laminin-5-dependent. Thus, deposition of laminin 5 can instruct keratinocytes to switch from an activated phenotype to a quiescent and integrated epithelial phenotype.

[Indexed for MEDLINE]

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