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Curr Opin Cell Biol. 2000 Oct;12(5):548-53.

Functions of alpha3beta1 integrin.

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Department of Medicine, Children's Hospital, and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Massachusetts 02115, Boston, USA.


alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.

[Indexed for MEDLINE]

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