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Curr Opin Cell Biol. 2000 Oct;12(5):542-7.

Avidity regulation of integrins: the driving force in leukocyte adhesion.

Author information

1
Department of Tumor Immunology, University Medical Center Nijmegen, St Radboud, P. Van Leydenlaan 25, 6525 EX, the, Nijmegen, Netherlands. Y.vanKooyk@dent.kun.nl

Abstract

The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.

PMID:
10978887
DOI:
10.1016/s0955-0674(00)00129-0
[Indexed for MEDLINE]

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