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Curr Opin Biotechnol. 2000 Aug;11(4):408-12.

Proteomics: applications in basic and applied biology.

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Large Scale Proteomics Corporation, Rockville, MD 20850, USA.


The rapid evolution of proteomics has continued during the past year, with a series of innovations in the core technologies of two-dimensional electrophoresis and mass spectrometry, and a diversity of productive research programmes. Well-annotated proteomics databases are now emerging in a number of fields to provide a platform for systematic research, with particularly promising progress in clinical applications such as cardiology and oncology. Large-scale quantitative research, comparable in power and sensitivity to that achieved for gene expression, is thus becoming a reality at the protein level.

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