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Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10436-41.

A genomewide survey of basic helix-loop-helix factors in Drosophila.

Author information

1
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143-0725, USA.

Abstract

The basic helix-loop-helix (bHLH) transcription factors play important roles in the specification of tissue type during the development of animals. We have used the information contained in the recently published genomic sequence of Drosophila melanogaster to identify 12 additional bHLH proteins. By sequence analysis we have assigned these proteins to families defined by Atonal, Hairy-Enhancer of Split, Hand, p48, Mesp, MYC/USF, and the bHLH-Per, Arnt, Sim (PAS) domain. In addition, one single protein represents a unique family of bHLH proteins. mRNA in situ analysis demonstrates that the genes encoding these proteins are expressed in several tissue types but are particularly concentrated in the developing nervous system and mesoderm.

PMID:
10973473
PMCID:
PMC27042
DOI:
10.1073/pnas.170301897
[Indexed for MEDLINE]
Free PMC Article

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