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Nat Immunol. 2000 Sep;1(3):234-8.

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.

Author information

1
Division of Molecular Immunology, German Cancer Research Center, im Neuenhelmer Feld 280, D-69120 Heidelberg, Germany.

Abstract

Tapasin is a component of the major histocompatibility complex (MHC) class I antigen-loading complex. Here we show that mice with a disrupted tapasin gene display reduced MHC class I expression. Cytotoxic T cell (CTL) responses to viruses are impaired, and dendritic cells of tapasin-deficient mice do not cross-present protein antigen via the MHC class I pathway, indicating a defect in antigen processing. Natural killer (NK) cells from tapasin-deficient mice have an altered repertoire and are self-tolerant. In addition, the repertoire of class I-bound peptides is altered towards less stably binding ones. Thus tapasin plays a role in CTL and NK immune responses and in optimal peptide selection.

PMID:
10973281
DOI:
10.1038/79775
[Indexed for MEDLINE]
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