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Nat Immunol. 2000 Sep;1(3):199-205.

Dendritic cell regulation of TH1-TH2 development.

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Département de Biologie Moleculaire, Université Libre de Bruxelles, Rue des Prof. Jeener et Brochet 12, 6041 Gosselies, Belgium.


Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence this process. Recent work suggests that dendritic cell subsets contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. In some cases known pathways may be used, as in the dendritic cell subset 1 exerting TH1 polarization by interleukin 12 (IL-12) production and STAT4 activation. In others, the effects are still in need of explanation.

[Indexed for MEDLINE]

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