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Clin Exp Immunol. 2000 Sep;121(3):437-43.

Significance of chemokines and activated platelets in patients with diabetes.

Author information

1
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan. fwkg4681@mb.infoweb.ne.jp

Abstract

Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin or plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on activation normally T-cell expressed and secreted (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from diabetic and control patients in order to develop a better understanding of their potential contribution to diabetic vascular complications. Significant increases were found for PMPs, plt:P-selectin, MCP-1, RANTES and soluble P- and E-selectins in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after ticlopidine treatment, most of these factors receded to baseline levels observed in non-diabetic patients. Our findings indicate that ticlopidine might be able to prevent or reduce vascular complications in diabetic patients.

PMID:
10971508
PMCID:
PMC1905738
DOI:
10.1046/j.1365-2249.2000.01324.x
[Indexed for MEDLINE]
Free PMC Article

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