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Dermatology. 2000;201(1):10-4.

Expressions of various growth factors and their receptors in tissues from neurofibroma.

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1
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Abstract

BACKGROUND:

Platelet-derived growth factor BB (PDGF-BB) and transforming growth factor beta are known to enhance the growth of neurofibroma-derived cells from neurofibromatosis type 1 (NF-1) patients.

OBJECTIVE:

This study aims to elucidate whether these growth factors and their receptors are up-regulated in NF-1 patients.

METHODS:

Tissues and culture cells from neurofibroma in NF-1 patients, nontumor lesions in NF-1 patients, and the skin of normal controls were collected. To evaluate the expressions of growth factors and their receptors, reverse-transcriptase polymerase chain reaction and immunohistochemistry were performed.

RESULTS:

PDGF-beta receptor subunit was expressed in the neurofibroma tissues from NF-1 patients, but not in the nontumorous tissues from NF-1 patients or skin from normal controls. As for the other factors, there were no significant differences among these tissues. Neurofibroma sections also stained positive for the PDGF-beta receptor subunit.

CONCLUSIONS:

The interaction of PDGF and PDGF-beta receptor subunit may be important in the tumorigenesis of NF-1.

PMID:
10971052
DOI:
18421
[Indexed for MEDLINE]
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