Prevention and therapeutic strategies for levodopa-induced dyskinesias in Parkinson's disease

Curr Opin Neurol. 2000 Aug;13(4):431-6. doi: 10.1097/00019052-200008000-00011.

Abstract

Levodopa-induced dyskinesias represent a major shortcoming of Parkinson's disease management, and its pharmacological treatment is generally unsatisfactory. However, the conclusive demonstration of the benefits associated with early prescription of a dopamine agonist, the antidyskinetic properties of 'old' antiparkinsonian compounds such as amantadine, and the striking results of functional stereotatic neurosurgery are extremely important advances for the treatment of levodopa-induced dyskinesias.

Publication types

  • Review

MeSH terms

  • Antiparkinson Agents / adverse effects*
  • Humans
  • Levodopa / adverse effects*
  • Movement Disorders / drug therapy
  • Movement Disorders / prevention & control*
  • Movement Disorders / surgery
  • Movement Disorders / therapy*
  • Parkinson Disease / drug therapy*

Substances

  • Antiparkinson Agents
  • Levodopa