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Curr Opin Neurol. 2000 Aug;13(4):377-84.

Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.

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Centre for Research in Neurodegenerative Diseases, Toronto, Ontario, Canada.


Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed to resolve any single cause of Alzheimer's disease and suggest a complex etiology, with environmental and genetic factors influencing the pathogenesis. Although the majority of cases are sporadic, a small number display familial clustering. Genetic analyses of these pedigrees have identified four genes that are involved in the development of Alzheimer's disease.

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