Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2000 Aug 21;10(16):1807-10.

4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.

Author information

1
Eli Lilly and Company Ltd, Lilly Research Centre, Windlesham, Surrey, UK. baker_s_richard@lilly.com

Abstract

Twenty-four 4-alkylidene glutamic acids were synthesised and tested as potential subtype selective GluR5 and 6 ligands. It was found that a critical size of alkylidene group gave potent and selective GluR5 receptor agonists. LY339624 had Kis of 0.0326 and >100 microM on GluR5 and 6 receptors, respectively.

PMID:
10969973
DOI:
10.1016/s0960-894x(00)00346-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center