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J Pediatr. 2000 Sep;137(3):421-4.

Increased oxidative stress in kwashiorkor.

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1
Department of Pediatrics, St Louis Children's Hospital, St Louis, Missouri 63110, USA.

Abstract

To test the hypothesis that kwashiorkor is associated with increased oxidative stress, urinary concentrations of 2 oxidized amino acids, o,o '-dityrosine and ortho -tyrosine, were measured by gas chromatography-mass spectrometry. Children with kwashiorkor, with or without infection, had a 3- to 7-fold increase in urinary o,o '-dityrosine and a 1.5- to 2-fold increase in ortho -tyrosine when compared with well-nourished children. This observation raises the possibility that oxidative damage to proteins and other biologic targets plays a role in the clinical manifestations of kwashiorkor.

PMID:
10969271
DOI:
10.1067/mpd.2000.107512
[Indexed for MEDLINE]
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