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Science. 2000 Sep 1;289(5484):1567-9.

Extension of life-span with superoxide dismutase/catalase mimetics.

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1
Buck Institute for Age Research, Novato, CA 94949, USA.

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

PMID:
10968795
[Indexed for MEDLINE]
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