Format

Send to

Choose Destination
FEMS Immunol Med Microbiol. 2000 Sep;29(1):39-45.

Staphylococcus aureus alpha-toxin induces apoptosis in endothelial cells.

Author information

1
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. barbara.e.menzies@vanderbilt.edu

Abstract

The internalization of Staphylococcus aureus by cultured human umbilical vein endothelial cells was recently shown to induce apoptosis. We examined the role of alpha-toxin, a major pore-forming toxin secreted by S. aureus, in causing apoptosis in vitro. Purified alpha-toxin, at sublytic concentrations, induced apoptosis in endothelial cell monolayers. Comparisons of two alpha-toxin (hla)-positive S. aureus strains and their isogenic hla-deficient mutants in the invasion assay of endothelial cells demonstrated that the capacity to produce alpha-toxin was associated with a greater propensity for apoptosis in endothelial cells. These results demonstrate for the first time that expression of alpha-toxin during endothelial cell invasion by S. aureus enhances apoptosis.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center