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Forensic Sci Int. 2000 Nov 13;114(2):107-15.

Relatedness testing in subdivided populations.

Author information

1
Department of Applied Statistics, University of Reading, P.O. Box 240, Earley Gate, RG6 6FN, Reading, UK. k.l.ayres@reading.ac.uk

Abstract

Assigning probabilities to alleged relationships, given DNA profiles, requires, among other things, calculation of a likelihood ratio (LR). Such calculations usually assume independence of genes: this assumption is not appropriate when the tested individuals share recent ancestry due to population substructure. Adjusted LR formulae, incorporating the coancestry coefficient F(ST), are presented here for various two-person relationships, and the issue of mutations in parentage testing is also addressed.

PMID:
10967251
DOI:
10.1016/s0379-0738(00)00289-9
[Indexed for MEDLINE]

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