Format

Send to

Choose Destination
Semin Cell Dev Biol. 2000 Aug;11(4):315-24.

MAGUK proteins: structure and role in the tight junction.

Author information

1
Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies (CINVESTAV), Ap. Postal 14-740, Mexico DF, 07000, Mexico. lorenza@fisio.cinvestav.mx

Abstract

ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression.

PMID:
10966866
DOI:
10.1006/scdb.2000.0178
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center