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Nat Neurosci. 2000 Sep;3(9):887-94.

Glutamate receptors regulate actin-based plasticity in dendritic spines.

Author information

1
Friedrich Miescher Institute, P.O. Box 2543, 4002 Basel, Switzerland.

Abstract

Dendritic spines at excitatory synapses undergo rapid, actin-dependent shape changes which may contribute to plasticity in brain circuits. Here we show that actin dynamics in spines are potently inhibited by activation of either AMPA or NMDA subtype glutamate receptors. Activation of either receptor type inhibited actin-based protrusive activity from the spine head. This blockade of motility caused spines to round up so that spine morphology became both more stable and more regular. Inhibition of spine motility by AMPA receptors was dependent on postsynaptic membrane depolarization and influx of Ca 2+ through voltage-activated channels. In combination with previous studies, our results suggest a two-step process in which spines initially formed in response to NMDA receptor activation are subsequently stabilized by AMPA receptors.

PMID:
10966619
DOI:
10.1038/78791
[Indexed for MEDLINE]

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