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Annu Rev Biochem. 2000;69:95-114.

Spindle assembly in animal cells.

Author information

1
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. duane.a.compton@dartmouth.edu

Abstract

Chromosome segregation during mitosis and meiosis is driven by a complex superstructure called the spindle. Microtubules are the primary structural component of spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of microtubules. This review summarizes spindle structure and highlights recent findings regarding the mechanisms and molecules involved in organizing microtubules into spindles. In addition, mechanisms for chromosome movement and segregation are discussed.

PMID:
10966454
DOI:
10.1146/annurev.biochem.69.1.95
[Indexed for MEDLINE]

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