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J Med Microbiol. 2000 Sep;49(9):845-7.

Clonal spread of an invasive strain of Haemophilus influenzae type b among nursery contacts accompanied by a high carriage rate of non-disease-associated strains.

Author information

1
Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. msaito@bact.med.kyushu-u.ac.jp

Abstract

Haemophilus influenza carriage was examined in unvaccinated nursery contacts of a patient with H. influenzae type b (Hib) meningitis and isolates were typed by pulsed-field gel electrophoresis (PFGE). Nasopharyngeal isolates were classified into eight PFGE patterns. Seven Hib carriers were found among 15 nursery contacts. The isolates from the carriers showed a PFGE pattern identical to that of the meningitis strain. The carrier rate of non-disease-associated strains was also high (47%, 7 of 15). This study suggests that the clonal spread of invasive (serotype b) H. influenzae strains is accompanied by a high carriage rate of non-disease-associated strains.

PMID:
10966235
DOI:
10.1099/0022-1317-49-9-845
[Indexed for MEDLINE]

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