Human herpesvirus 6-meningoencephalitis in an HIV patient with progressive multifocal leukoencephalopathy

Acta Neuropathol. 2000 Sep;100(3):337-41. doi: 10.1007/s004010000198.

Abstract

Human herpesvirus 6 (HHV6) has been reported as a rare cause of meningoencephalitis and leukoencephalitis. We present an HIV-infected patient with lesions of progressive multifocal leukoencephalopathy (PML), but also meningoencephalitis apparently due to HHV6. Immunohistochemistry for HHV6 antigens and in situ polymerase chain reaction for HHV6 genome showed many positive lymphocytes and microglia in the meningeal and cortical lesions. More importantly, dead and dying neurons were conspicuous; some were undergoing neuronophagia and some displayed evidence of HHV6 infection. A pathogenic role for this almost universal, and usually commensal, virus in inflammatory brain lesions and PML is briefly discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology
  • Brain / virology*
  • HIV Infections / complications*
  • HIV Infections / pathology
  • HIV Infections / physiopathology
  • Herpesviridae Infections / complications*
  • Herpesviridae Infections / pathology
  • Herpesviridae Infections / physiopathology
  • Herpesvirus 6, Human / pathogenicity*
  • Humans
  • Inflammation / pathology
  • Inflammation / physiopathology
  • Inflammation / virology
  • Leukoencephalopathy, Progressive Multifocal / complications
  • Leukoencephalopathy, Progressive Multifocal / pathology
  • Leukoencephalopathy, Progressive Multifocal / virology*
  • Lymphocytes / pathology
  • Lymphocytes / virology
  • Male
  • Meningoencephalitis / complications
  • Meningoencephalitis / pathology
  • Meningoencephalitis / virology*
  • Neuroglia / pathology
  • Neuroglia / virology
  • Plasma Cells / pathology
  • Plasma Cells / virology