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Dev Biol. 2000 Sep 1;225(1):188-200.

Endogenous and ectopic gland induction by FGF-10.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA.

Abstract

FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.

PMID:
10964474
DOI:
10.1006/dbio.2000.9812
[Indexed for MEDLINE]
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