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Nature. 2000 Aug 17;406(6797):788-92.

CD1-restricted T-cell responses and microbial infection.

Author information

1
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Abstract

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

PMID:
10963609
DOI:
10.1038/35021233
[Indexed for MEDLINE]

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