Format

Send to

Choose Destination
Nature. 2000 Aug 17;406(6797):782-7.

Toll-like receptors in the induction of the innate immune response.

Author information

1
Department of Immunology, University of Washington, Seattle 98195, USA.

Abstract

The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

PMID:
10963608
DOI:
10.1038/35021228
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center